Publications by authors named "P Diaz de la Torre"
Hepatitis C is a disease for which in approximately 30 years we have gone from the discovery of the causative agent in 1989, to the introduction of direct-acting antiviral (DAAs) therapies starting from 2011, and to a proposal for its elimination in 2016, with some countries being on track for this goal. Elimination efforts, in the absence of a vaccine, rely on prevention measures and antiviral therapies. However, treatment rates have declined in recent years and are not considered adequate to achieve this goal at a global level.
View Article and Find Full Text PDFArticle Synopsis
- Polycystic Kidney and Hepatic Disease 1-Like 1 (PKHD1L1) is a gene linked to autosomal recessive deafness (DFNB124) and is essential for the proper functioning of sensory hair cells in the cochlea, which are crucial for hearing.
- The study investigates PKHD1L1 expression in mice throughout various developmental stages and its role in hair-cell bundle structure, revealing that absence of this gene leads to issues with stereocilia starting at 6 weeks of age.
- PKHD1L1-deficient mice exhibit progressive hearing loss with age and are more vulnerable to permanent damage from noise exposure, highlighting the gene's importance in maintaining auditory function during development and against environmental
Hypertension is the leading risk for cardiovascular disease and worldwide mortality. Uncontrolled blood pressure worsens with age and its control is part of public health strategies especially for older adults. Telomere length (TL) has been associated with hypertension, with age and sex as relevant confounding factors, but it is not clear whether hypertension control in older adults impacts on TL and if this relationship is consistently age and sex dependent.
View Article and Find Full Text PDFMitochondrial optic atrophy-1 (OPA1) plays key roles in adapting mitochondrial structure to bioenergetic function. When transmembrane potential across the inner membrane (Δψ) is intact, long (L-OPA1) isoforms shape the inner membrane through membrane fusion and the formation of cristal junctions. When Δψ is lost, however, OPA1 is cleaved to short, inactive S-OPA1 isoforms by the OMA1 metalloprotease, disrupting mitochondrial structure and priming cellular stress responses such as apoptosis.
View Article and Find Full Text PDFArticle Synopsis
- The study revisits the anatomy of cysticerci in common strains (WFU and ORF), utilizing conventional staining and confocal microscopy to update existing knowledge on their muscle and neural architecture.
- The research highlights differences in developmental polarization processes between the two strains, shedding light on their unique characteristics.
- Additionally, the study investigates genes linked to peptidergic neural functions in related flatworms, contributing to a better understanding of the presence or absence of the scolex in these strains.