Discontinuing cannabis use: Symptomatic and functional outcomes in people with an established psychotic disorder.

For people with psychotic disorders, the negative outcomes associated with continuing cannabis use would suggest that discontinuing such use may be beneficial for their symptomatic and functional recovery. However, existing evidence that discontinuation is associated with better clinical outcomes is inconsistent and it remains unclear whether discontinuing use is associated with improvements in outcomes for people with an established psychotic disorder. In this 3-5-year longitudinal study we examined baseline and follow-up symptomatic and functional profiles of 371 people with an established psychotic disorder, comparing those who continued to use cannabis with those who discontinued use after baseline assessment.

Development and initial validation of a multivariable predictive Early Adversity Scale for Schizophrenia (EAS-Sz) using register data to quantify environmental risk for adult schizophrenia diagnosis after childhood exposure to adversity.

Background: Additional to a child's genetic inheritance, environmental exposures are associated with schizophrenia. Many are broadly described as childhood adversity; modelling the combined impact of these is complex. We aimed to develop and validate a scale on childhood adversity, independent of genetic and other environmental liabilities, for use in schizophrenia risk analysis models, using data from cross-linked electronic health and social services registers.

Hospital inpatient admissions of children of mothers with severe mental illness: A Western Australian cohort study.

Background: Children of parents with mental illness face a number of adversities, potentially contributing to poor health.

Aim: The aim of this study was to quantify the association between maternal severe mental illness and children's hospital admissions.

Method: Record linkage cohort study of 467,945 children born in Western Australia between 1 January 1980 and 31 December 2001.