Publications by authors named "P Di Filippo"
Microplastics are mostly inert particles and, therefore, may exhibit low toxicity, but adverse health effects may result from chemical additives commonly added to plastics. Plastic additives serve to make the material workable and thermodynamically stable as well as acting as softeners, fillers and colorants. They may include hazardous chemicals, such as organic phosphates, phthalates, terephthalates, adipates, benzoates, citrates, sebacates, trimellitates, etc.
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- Acute respiratory failure (ARF) is a sudden condition where the respiratory system fails to provide enough oxygen, often caused by diseases like pneumonia, asthma, and neuromuscular disorders, particularly affecting children more severely than adults.
- Diagnosing ARF in children is challenging due to their inability to express symptoms and their limited cooperation during tests, making clinical assessments crucial for identifying the severity and underlying causes.
- Effective treatment involves immediate actions like providing oxygen and possibly mechanical ventilation, while the review highlights advancements in understanding ARF through new imaging techniques, biomarkers, and the use of artificial intelligence.
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- Defibrillation leads are crucial for implantable cardioverter-defibrillators (ICDs), and the LEADR trial tested the new OmniaSecure lead, showing strong safety, efficacy, and zero fractures over about 13 months.
- The study aimed to project the long-term, 10-year fracture-free survival of the OmniaSecure lead using advanced reliability modeling and in-vivo imaging techniques.
- Results indicated a 98.2% projected fracture-free survival rate over 10 years for the OmniaSecure lead, especially beneficial for adolescents, surpassing the performance of existing leads.
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- Cyanoacrylate-based adhesives are commonly used for wound closure, offering good cosmetic outcomes and minimal discomfort, but they may release harmful chemicals during biodegradation.
- The study evaluated four types of cyanoacrylate adhesives and nylon stitches on skin incisions in 140 animals, finding that n-2-octyl-cyanoacrylate (G4) resulted in faster wound closure, while nylon stitches (G5) showed initially greater strength but decreased over time.
- Overall, cyanoacrylate adhesives led to less inflammation and quicker healing compared to nylon sutures, with varying effects on cell response and collagen types among the groups studied.
Alemtuzumab, a humanized anti-CD52 monoclonal antibody, is approved for treatment of highly active relapsing multiple sclerosis (MS) but requires vigilant post-treatment monitoring due to associated risks. The prescription of subsequent therapies following Alemtuzumab, as mandated by label guidance for a treatment-free period of at least 5 years, presents a complex challenge, particularly if there is concurrent conversion to secondary progressive disease course. We described a case-series of five patients starting therapy with Siponimod and followed up for 12 months period converted to secondary progressive MS previously exposed to Alemtuzumab.
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