Publications by authors named "P Di Costanzo"
Introduction And Objectives: Chronic obstructive pulmonary disease (COPD) frequently coexists with other comorbidities, including hypogonadism. However, the association between COPD severity and hypogonadism remains controversial. This study aimed to evaluate this association and compare the clinical characteristics of hypogonadal and eugonadal COPD patients.
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- Hypogonadism is commonly found in men with chronic obstructive pulmonary disease (COPD), with this study aiming to compare its prevalence in men with and without the condition.
- The study involved 134 men with stable COPD and 70 age-matched control men, finding that 41.8% of COPD patients had hypogonadism compared to just 10.0% in non-COPD men.
- Results indicate that COPD significantly increases the likelihood of hypogonadism, especially in more severe cases, suggesting the need for routine screening of hormonal levels in COPD patients.
Article Synopsis
- - The study focuses on creating hybrid molecules as a strategy for drug discovery, emphasizing the significance of 1,2,3-triazole as a key component in medicinal chemistry.
- - Researchers designed and synthesized new 1,2,3-triazole hybrids incorporating isatine and phenolic elements, utilizing a click chemistry approach for efficient synthesis.
- - A molecular docking study identified four therapeutic targets for these hybrids, with the most promising results related to 5-lipoxygenase, which plays a role in inflammation.
Mercury pollution poses a global health threat due to its high toxicity, especially in seafood where it accumulates through various pathways. Developing effective and affordable technologies for mercury removal from water is crucial. Adsorption stands out as a promising method, but creating low-cost materials with high selectivity and capacity for mercury adsorption is challenging.
View Article and Find Full Text PDFThe limited solubility of natural cellulose in water and common organic solvents hinders its diverse applications, despite being one of the most abundant and easily accessible biopolymers on Earth. Chemical derivatization, such as cellulose carbamate (CC), offers a pathway to enhance both solubility and industrial processability. In this study, CC was synthesized by exploiting a novel type IV deep eutectic solvent (DES) composed of erbium trichloride and urea.
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