Larger sample sizes are needed when developing a clinical prediction model using machine learning in oncology: methodological systematic review.

Background: Having a sufficient sample size is crucial when developing a clinical prediction model. We reviewed details of sample size in studies developing prediction models for binary outcomes using machine learning (ML) methods within oncology and compared the sample size used to develop the models with the minimum required sample size needed when developing a regression-based model (N).

Methods: We searched the Medline (via OVID) database for studies developing a prediction model using ML methods published in December 2022.

Recent developments in photo-fermentative hydrogen evolution: Fundamental biochemistry and influencing factors a review.

The global shift towards renewable energy sources highlights the urgent need for sustainable hydrogen production, with photo-fermentative hydrogen evolution (PFHP) emerging as a promising solution. This review addresses the challenges and opportunities in optimizing PFHP, specifically the role of photosynthetic bacteria (PBS) in utilizing sunlight for hydrogen production. We focus on the key factors influencing PFHP, including light intensity, reactor design, substrate selection, carbon-to-nitrogen ratio, metal ions, temperature, pH, charge transfer and genetic engineering.

Real-World Evidence on the Effectiveness of Pembrolizumab in Patients With Recurrent/Metastatic/Unresectable Head and Neck Squamous Cell Cancer: A Systematic Review and Meta-Analysis.

The aim of the review was to systematically review real-world data on the effectiveness and safety of pembrolizumab in recurrent/metastatic/unresectable head and neck squamous cell cancer (HNSCC) patients. Two independent reviewers retrieved the studies separately and simultaneously. PubMed, Embase, Scopus, Web of Science, and Cochrane Central were searched for prospective and retrospective studies on recurrent/metastatic/unresectable HNSCC patients treated with either pembrolizumab monotherapy or pembrolizumab combination therapy published till November 2024.

Neuronal nitric oxide synthase activation by tadalafil protects neurological impairments in a zebrafish larva model of hyperammonemia.

Aims: Hyperammonaemia (HA) is a metabolic disorder characterized by increased ammonia levels in the blood and is associated with severe neurological impairments. Some previous findings have shown the involvement of the nitric oxide pathway in HA-induced neurological impairments. The current study explored the impact of tadalafil on neurological impairments induced by HA in a zebrafish larval model due to its reported indirect interactions with the nitric oxide pathway.

Polysaccharide-based biopolymeric magnetic hydrogels for remediation of antibiotics from aqueous solution.

Polysaccharide-based biopolymeric magnetic hydrogels have garnered significant attention as effective materials for wastewater treatment due to their high adsorption capacity and environmentally friendly nature. This review examines recent advancements in the development of biopolymeric magnetic hydrogels derived from polysaccharides such as cellulose, chitosan, alginate, carrageenan, starch, and gums, with a focus on their application in removing antibiotics from contaminated water as it not only enhances adsorption performance but also simplifies separation processes after treatment, making them highly efficient for practical applications. The review aims to provide a comprehensive overview of the synthesis techniques, performance characteristics, and interaction mechanisms of these hydrogels, highlighting their renewability and suitability for large-scale water treatment.