Rationalizing mAb Candidate Screening Using a Single Holistic Developability Parameter.

A framework for the rational selection of a minimal suite of nondegenerate developability assays (DAs) that maximize insight into candidate developability or storage stability is lacking. To address this, we subjected nine formulation:mAbs to 12 mechanistically distinct DAs together with measurement of their accelerated and long-term storage stability. We show that it is possible to identify a reduced set of key variables from this suite of DAs by using orthogonal statistical methods.

Is there truth in fiction? Lessons from readers' responses to dementia fiction.

This paper addresses the question 'is there truth in fiction?', by synthesising a range of disciplinary approaches to the issue, as well as drawing on empirical research carried out with readers of fiction about dementia (hereafter, dementia fiction). We argue that fiction-perhaps because of its fictional status and apparatus-invites readers to consider its truth value, to explore the possibilities of human experience and interrogate issues relative to their subjective experience, community or society. The findings have significant implications for the Medical Humanities' use of fictional texts to explore lived medical conditions and experiences, as well as claims made about the potential for fiction to affect real-world understandings, awareness and empathy around the conditions depicted.

Empowering behaviors to address race with kids (EmBARK): A racial socialization program for white families.

We evaluated the EmBARK (Empowering Behaviors to Address Race with Kids) program, which we developed to help White parents in the US address race and racial biases with their White 5- to 7-year-old children. Parents ( = 73) completed EmBARK or control condition activities matched for time commitment and engagement with their child. We achieved remarkable compliance with EmBARK, with 95% of parents completing every program component.

To 200,000 / and Beyond: Native Electron Capture Charge Reduction Mass Spectrometry Deconvolves Heterogeneous Signals in Large Biopharmaceutical Analytes.

Great progress has been made in the detection of large biomolecular analytes by native mass spectrometry; however, characterizing highly heterogeneous samples remains challenging due to the presence of many overlapping signals from complex ion distributions. Electron-capture charge reduction (ECCR), in which a protein cation captures free electrons without apparent dissociation, can separate overlapping signals by shifting the ions to lower charge states. The concomitant shift to higher / also facilitates the exploration of instrument upper / limits if large complexes are used.