Publications by authors named "P Denny"
We employed a BONCAT-iTRAQ labelling approach to investigate newly synthesised proteins (NSPs) in subjected to varying concentrations of the antifolate drug pyrimethamine. Our results reveal that numerous NSPs exhibited altered expression levels in response to the drug, with significant upregulation observed at higher concentrations. Key proteins involved in protein synthesis, stress responses, energy metabolism, and cytoskeletal dynamics were identified, indicating that undergoes complex adaptive responses to pyrimethamine treatment.
View Article and Find Full Text PDFCamera-based object detection is integral to advanced driver assistance systems (ADAS) and autonomous vehicle research, and RGB cameras remain indispensable for their spatial resolution and color information. This study investigates exposure time optimization for such cameras, considering image quality in dynamic ADAS scenarios. Exposure time, the period during which the camera sensor is exposed to light, directly influences the amount of information captured.
View Article and Find Full Text PDFIn recent years, significant advances have been made in the development of Advanced Driver Assistance Systems (ADAS) and other technology for autonomous vehicles. Automated object detection is a crucial component of autonomous driving; however, there are still known issues that affect its performance. For automotive applications, object detection algorithms are required to perform at a high standard in all lighting conditions; however, a major problem for object detection is poor performance in low-light conditions due to objects being less visible.
View Article and Find Full Text PDFArticle Synopsis
- * Inositol phosphorylceramide (IPC) plays a key role in leishmania species, with IPC synthase (IPCS) being a critical enzyme; clemastine fumarate has emerged as a potential IPCS inhibitor and an anti-leishmanial agent.
- * Research reveals that while clemastine fumarate inhibits IPCS and alters metabolic pathways, its main action may involve different targets, suggesting further investigation is needed for effective treatment strategies.
Objective: The aims of this scoping review were to summarize the evidence regarding sex, racial, ethnic, geographic, and socioeconomic disparities in post-acute rehabilitation following total hip arthroplasty (THA) and knee arthroplasty (TKA).
Methods: Literature searches were conducted in Ovid MEDLINE, EMBASE, CINAHL, Web of Science, and PEDro. Studies were included if they were original research articles published 1993 or later; used data from the US; included patients after THA and/or TKA; presented results according to relevant sociodemographic variables, including sex, race, ethnicity, geography, or socioeconomic status; and studied the utilization of post-acute rehabilitation as an outcome.