Publications by authors named "P Deepthy Antony"
Insights into the interaction between hemorphins and δ-opioid receptor from molecular modeling.
Front Mol Biosci
December 2024
Hemorphins are short atypical opioid peptide fragments embedded in the β-chain of hemoglobin. They have received considerable attention recently due to their interaction with opioid receptors. The affinity of hemorphins to opioid receptors μ-opioid receptor (MOR), δ-opioid receptor (DOR), and κ-opioid receptor (KOR) has been well established.
View Article and Find Full Text PDFPredicting most comfortable listening levels of ESRT from ECAP thresholds in paediatric cochlear implant users.
Int J Pediatr Otorhinolaryngol
December 2024
Studies have reported a varied correlation strength between the electrically evoked compound action potential (ECAP) and electrically evoked stapedial reflex thresholds (ESRT) in cochlear implant recipients. However, there is a lack of information on the relationship between the two measures in paediatric cochlear implant users. This study was aimed to compare the ESRT and ECAP measures and determine where ECAP thresholds fall within the dynamic range of ESRT-based Maps in paediatric cochlear implant users.
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- Metabolic syndrome, which includes obesity, diabetes, and high blood pressure, is common in bipolar disorder patients, and this study highlights the lack of research from India on this issue.
- A study involving 83 bipolar patients was conducted to assess the prevalence of metabolic syndrome using specific diagnostic criteria, alongside evaluation of mood severity and suicidal risk.
- Results showed that 59% of the patients had metabolic syndrome, associated with more severe manic episodes and a greater risk of suicide, particularly in those taking multiple medications.
Parkinson's disease, an aging-associated neurodegenerative disorder, is characterised by nigrostriatal pathway dysfunction caused by the gradual loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain. Human in vitro models are enabling the study of the dopaminergic neurons' loss, but not the dysregulation within the dopaminergic network in the nigrostriatal pathway. Additionally, these models do not incorporate aging characteristics which potentially contribute to the development of Parkinson's disease.
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- Pathogenic variants in the LRRK2 gene significantly contribute to Parkinson's disease, but not everyone with these variants develops the disease, suggesting lifestyle and environmental factors play a role.
- A study analyzed household dust samples from different groups, including patients with and without PD and a healthy control group, identifying over 1,000 chemicals and 163 types of microorganisms, with some shown to be statistically significant in relation to PD.
- Notably, hazardous chemicals like Bisphenol S were linked to negative effects on mitochondrial function in nerve cells from PD patients, highlighting the potential impact of environmental exposures on Parkinson's disease development.