The Chromatin-Oxygen Sensor Gene Associates with Novel Hypoxia-Related Signatures in Glioblastoma Multiforme.

Glioblastoma multiforme (GBM) is a fatal brain tumor without effective drug treatment. In this study, we highlight, for the first time, the contribution of chromatin remodeling gene Lysine (K)-specific demethylase 5C () in GBM via an extensive analysis of clinical, expression, and functional data, integrated with publicly available omic datasets. The expression analysis on GBM samples (N = 37) revealed two informative subtypes, namely KDM5C and KDM5C, displaying higher/lower KDM5C levels compared to the controls.

Dramatic response to regorafenib in early glioblastoma progression: case report and review of the literature.

Background: Glioblastoma (GBM) is a highly lethal disease despite integrated treatment comprising radiotherapy plus concomitant and adjuvant temozolomide, with a median overall survival of less than 15 months. For recurrent glioblastoma, there is yet no standard therapy, considering that Bevacizumab have failed to improve overall survival (OS) while regorafenib had a little benefit over standard chemotherapy. In addition, the disease control rate is almost exclusively stability, with a poor objective response rate.

Malignant Intracerebral Nerve Sheath Tumor Presenting With Intratumoral Hemorrhage.

Background: Primary central nervous system sarcomas are rare primitive mesenchymal non-meningothelial tumors. Malignant peripheral nerve sheath tumor accounts for 5% of sarcomas, with an incidence of approximately 0.001% and a recognized association with neurofibromatosis type 1.

Participatory analytic hierarchy process for resource allocation in agricultural development projects.

In the framework of 2030 Agenda sustainable agriculture plays a central role. In the field of international aid the participatory approaches to assessment, research, management and budgeting have been widely studied and applied in the last decades, mostly because international aid initiatives, in all their relevant phases from planning through implementation, monitoring and evaluation, are faced with the problem of identifying initiatives that could be successfully and sustainably implemented. The present paper investigates the use of a modified form of analytic hierarchy process, namely the participatory analytic hierarchy process, as a tool for choice criteria elicitation and resource allocation in the framework of an operational planning for agricultural development projects in the Dioceses of Goma, Nord Kivu, Democratic Republic of Congo.