Parkinson's disease arises from the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to motor symptoms such as akinesia, rigidity, and tremor at rest. The non-motor component of Parkinson's disease includes increased neuropathic pain, the prevalence of which is 4 to 5 times higher than the general rate. By studying a mouse model of Parkinson's disease induced by 6-hydroxydopamine, we assessed the impact of dopamine depletion on pain modulation.
View Article and Find Full Text PDFThe exploration of increasingly specific brain structures and their relationships, in more nuanced ways, has facilitated the generation of databases for gene expression, connectivity, cell morphology, and electrophysiology. However, neurochemistry, the study of neurochemical environment and transmission, has not yet warranted a public database, despite the plethora of data published. From our viewpoint, a neurochemical database is overdue and would allow the field of neurochemistry to develop facilitating, standardization and reference values, reproducibility, resource efficiency, preservation and accessibility of raw data, hypothesis development and exploration, and metadata analysis.
View Article and Find Full Text PDFProg Neuropsychopharmacol Biol Psychiatry
December 2024
The antidepressant-like activity of two psychoplastogens, ibogainalog (IBG) and ibogaminalog (DM506), was studied in naïve mice using the forced swim test (FST) and tail suspension test (TST). The behavioral results showed that a single administration of 25 mg/kg DM506 or 10 mg/kg IBG induced antidepressant-like activity in naïve mice in a volinanserin-sensitive manner that persisted for 72 h. Similar results were observed using the chronic immobilization stress (CIS) test, in which depression symptoms were reduced for 48 h.
View Article and Find Full Text PDFInt J Biochem Cell Biol
November 2024
The study of the mechanism of action of classical psychedelics has gained significant interest due to their clinical potential in the treatment of several psychiatric conditions, including major depressive and anxiety disorders. These drugs bind 5-hydroxytryptamine receptors (5-HTR) including 5-HTR, 5-HTR, 5-HTR, and/or 5-HTR, as well as other targets. 5-HTRs regulate the activity of ascending monoaminergic neurons, a mechanism primarily involved in the action of classical antidepressant drugs, antipsychotics, and drugs of abuse.
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