Publications by authors named "P Dalvi"
Background: Tumor Necrosis Factor (TNF) are expressed in milk. Experimental data indicate enhanced brain growth and cognitive development in the mouse offspring given milk deficient in TNF and TNF-dependent chemokines. Although monoclonal antibodies against TNF (TNFmAb) are used during breastfeeding due to minimal milk excretion, whether it affects endogenous TNF levels in human milk is unclear.
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- Lactating mothers on ezetimibe may be reluctant to breastfeed due to uncertainties about its effects, as no existing data on the drug’s presence in breast milk have been available until now.* -
- Researchers collected breast milk samples from mothers taking ezetimibe to develop a method for measuring the drug and its metabolite, demonstrating low concentrations in the milk and predicting minimal exposure for breastfeeding infants.* -
- The study’s findings indicate that breastfed infants would receive negligible amounts of ezetimibe, suggesting breastfeeding remains safe; further research involving mother-infant pairs is recommended to confirm these results.*
Aims: Doxorubicin (DXR) is a chemotherapeutic agent that causes dose-dependent cardiotoxicity. Recently, it has been proposed that the NADase CD38 may play a role in doxorubicin-induced cardiotoxicity (DIC). CD38 is the main NAD+-catabolizing enzyme in mammalian tissues.
View Article and Find Full Text PDFBackground: The heterogenic manifestations of polycystic ovarian syndrome have led to various treatment approaches that include improving hormonal imbalance, weight management, and improving quality of life (QoL). Yoga therapy being a versatile treatment approach benefits physical and mental well-being and can be recommended to women with polycystic ovary syndrome (PCOS).
Objective: The objective of this study was to study the effect of structured yoga intervention on anthropometric, metabolic, hormonal, biochemical, ovarian morphology, and infertility-related QoL parameters among infertile women with PCOS.
The functionally pleiotropic ectoenzyme CD38 is a glycohydrolase widely expressed on immune and non-hematopoietic cells. By converting NAD to ADP-ribose and nicotinamide, CD38 governs organismal NAD homeostasis and the activity of NAD-dependent cellular enzymes. CD38 has emerged as a major driver of age-related NAD decline underlying adverse metabolic states, frailty and reduced health span.
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