Publications by authors named "P Dacosta Noble"
With the impending 'retirement' of bronchial thermoplasty (BT) for the treatment of patients with asthma, there is much to learn from this real-world experiment that will help us develop more effective future therapies with the same primary target i.e., airway smooth muscle (ASM) remodelling.
View Article and Find Full Text PDFComparative evaluation of two simulation technologies for obstetric ultrasound trainees' assessment.
Eur J Obstet Gynecol Reprod Biol
January 2025
Objective: The objective was to evaluate the performance of two different obstetric ultrasound simulators in assessing the practical skills of trainees compared to the standard method of practical assessment conducted on pregnant women volunteers.
Methods: We performed a prospective observational study. Two simulators were compared: the Simbionix simulator which uses a mannequin and heteroevaluation and the OPUS simulator which uses optical positioning technology with automatic assessment.
Article Synopsis
- Early lung function deficits can begin in childhood and are linked to developmental issues, leading to long-term risks for diseases like asthma and COPD.
- Suboptimal fetal development, marked by low birth weight and intrauterine growth restriction, increases the likelihood of obstructive diseases later in life.
- Prenatal exposures affecting growth can cause various structural and physiological abnormalities, highlighting the importance of early interventions, such as nutrition or antioxidant therapy, to support healthy lung development.
Organismal death has long been considered the irreversible ending of an organism's integrated functioning as a whole. However, the persistence of functionality in organs, tissues, and cells postmortem, as seen in organ donation, raises questions about the mechanisms underlying this resilience. Recent research reveals that various factors, such as environmental conditions, metabolic activity, and inherent survival mechanisms, influence postmortem cellular functionality and transformation.
View Article and Find Full Text PDFArticle Synopsis
- Monitoring mortality rates in pets provides important public health insights, highlighting how diseases affect animal well-being and guiding policy decisions.
- A study analyzed data from over 52,000 pets in the UK, revealing key findings like behavioral conditions considerably contributing to premature deaths in young dogs and a 19% higher mortality risk in certain dog breeds.
- The research also showed a strong link between socioeconomic status and pet mortality, with impoverished areas experiencing nearly a 50% higher risk of premature death in cats and dogs, pointing to the need for addressing these disparities to improve animal health.