Publications by authors named "P DE LA BARREDA"

Objectives: The number of kidney transplants obtained from controlled donations after circulatory death is increasing, with long-term outcomes similar to those obtained with donations after brain death. Extraction using normothermic regional perfusion can improve results with controlled donors after circulatory death; however, information on the histological impact and extraction procedure is scarce.

Materials And Methods: We retrospectively investigated all kidney transplants performed from October 2014 to December 2019, in which a follow-up kidney biopsy had been performed at 1-year follow-up, comparing controlled procedures with donors after circulatory death and normothermic regional perfusion versus donors after brain death.

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Tacrolimus has a narrow therapeutic margin. Maintaining tacrolimus blood levels in the appropriate range is difficult because of its intrapatient variability. In fact, greater blood level variability has been related to worse kidney graft outcome, but only measuring variability does not consider the therapeutic range goal.

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The pressure for Water Resource Recovery Facilities (WRRF) operators to efficiently treat wastewater is greater than ever because of the water crisis, produced by the climate change effects and more restrictive regulations. Technicians and researchers need to evaluate WRRF performance to ensure maximum efficiency. For this purpose, numerical techniques, such as CFD, have been widely applied to the wastewater sector to model biological reactors and secondary settling tanks with high spatial and temporal accuracy.

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Introduction: We aimed to evaluate if ex vivo machine perfusion could minimize the negative impact of cold ischemia on those renal grafts obtained from controlled donation after circulatory death (cDCD).

Material And Methods: Prospective observational paired study of kidney transplants from cDCD performed in our center. The kidney from each pair preserved on ice was transplanted first within the first few hours following procurement, while the contralateral kidney was machine-perfused with a LifePort device (Organ Recovery Systems, Brussels, Belgium) and transplanted the following day.

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Article Synopsis
  • Patients with end-stage renal disease have a high mortality rate, primarily due to cardiovascular issues, particularly arrhythmias, which contribute to about 50% of deaths in those on hemodialysis.
  • The study aimed to explore the connection between alterations in the QTc interval (due to electrolyte imbalances or genetic variants) and sudden cardiac deaths in hemodialysis patients.
  • Findings showed a potential link between long QTc intervals and increased mortality, with genetic analysis revealing rare variants in some patients who experienced sudden death, suggesting the importance of monitoring QTc intervals and conducting genetic tests for patients with long QTc post-dialysis.
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