Publications by authors named "P D Wadhwa"

Article Synopsis
  • This review focuses on genetic mutations in kinases related to Parkinson's Disease and analyzes both existing treatments and potential new therapeutic targets.
  • The study highlights four key kinases—PINK1, LRRK2, GAK, and PRKRA—emphasizing that LRRK2 has the most marketed inhibitors, while PINK1, GAK, and PRKRA remain largely unexplored.
  • It calls for increased research on these underinvestigated kinases to develop new therapies that could improve treatment options and address the progression of Parkinson's Disease.
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Renal calyceal diverticula are rarely diagnosed in children. Calculus formation within the diverticulum is a significant complication and its management in children remains controversial. We report our experience with 1 case, managed with minimally invasive surgery.

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Robust segmentation is critical for deriving quantitative measures from large-scale, multi-center, and longitudinal medical scans. Manually annotating medical scans, however, is expensive and labor-intensive and may not always be available in every domain. Unsupervised domain adaptation (UDA) is a well-studied technique that alleviates this label-scarcity problem by leveraging available labels from another domain.

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Unlabelled: Class II malocclusion is the most common issue encountered in orthodontic practice. Myofunctional appliances are the most effective treatment option for skeletal class II malocclusion in growing age. Twin block is the most commonly used removable functional appliance, although its success is dependent upon patient compliance.

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Background: Childhood maltreatment (CM) has long-term consequences for the regulation of stress biology which are particularly pronounced when mental and physical health sequelae have manifested. C-reactive protein (CRP) has been shown to be elevated in the non-pregnant state in association with CM as well as in the setting of CM-associated mental and physical health sequelae. In pregnancy, however, the association between CM and CRP is less clear.

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