Publications by authors named "P D Shearer"
Pregnancy failure is a serious economic and welfare concern in the Thoroughbred horse industry, yet its incidence and risk factors in Australia remain unclear. This retrospective, nested, case-control study investigated pregnancy failure in resident mares on studs in the Hunter Valley, Australia, in 2021-2022, in early (46-150 days), mid (151-270 days), and late (>270 days) gestation. We found an annual incidence risk of 5.
View Article and Find Full Text PDFAirway epithelial cells (AECs) play a key role in maintaining lung homeostasis, epithelium regeneration and the initiation of pulmonary immune responses. To isolate and study murine AECs investigators have classically used short and hot (1h 37°C) digestion protocols. Here, we present a workflow for efficient AECs isolation and culture, utilizing long and cold (20h 4°C) dispase II digestion of murine lungs.
View Article and Find Full Text PDFThe destructive 2023 moment magnitude () 7.8-7.7 earthquake doublet ruptured multiple segments of the East Anatolian Fault system in Turkey.
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- T cell responses to infections and cancer are guided by conventional dendritic cells (cDCs) in lymph nodes, which interact with migratory cDCs that transport antigens from the site of challenge.
- Research reveals that both tissue and lymph node cDCs work together, influenced by contextual signals, to determine the quality of T cell activation.
- The study shows that in different environments, such as tumors versus infections, cDC activation varies, affecting how antigens are processed and T cell responses are directed in the lymph nodes.
Urothelial carcinomas (UCs), also known as transitional cell carcinomas, are the most common canine urinary tract neoplasms. Tyrosine kinases (TKs) are enzymes that tightly regulate cell growth and differentiation through phosphorylation. Receptor TK (RTK) inhibitors are currently used to treat UCs.
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