Publications by authors named "P D Schellinger"
Article Synopsis
- The study investigates the effectiveness of high-resolution nerve ultrasound (HRUS) in diagnosing polyneuropathy caused by the chemotherapy drug vincristine.
- Twelve patients undergoing vincristine treatment and twelve healthy controls participated, with measurements taken at various intervals, including nerve cross-sectional areas (CSAs), neuropathy scores, and nerve conduction studies.
- Results indicated that while overall CSA at nerve entrapment sites increased alongside clinical symptoms, HRUS did not show significant changes at individual nerve sites, highlighting that clinical exams are key for early detection of vincristine-induced polyneuropathy.
Article Synopsis
- The European Stroke Organisation recommends using tenecteplase (TNK) as an alternative to alteplase (TPA) for treating acute ischemic stroke within 4.5 hours, based on previous studies establishing its noninferiority.
- An updated systematic review and meta-analysis assessed the efficacy and safety of TNK compared to TPA, using data from 11 randomized controlled trials involving nearly 7,600 patients.
- Results showed that TNK was linked to better chances of achieving excellent functional outcomes and reduced disability at 3 months, while maintaining similar safety profiles for symptomatic intracranial hemorrhage when compared to TPA.
Background: Emerging evidence suggests that endovascular thrombectomy is beneficial for treatment of childhood stroke, but the safety and effectiveness of endovascular thrombectomy has not been compared with best medical treatment. We aimed to prospectively analyse functional outcomes of endovascular thrombectomy versus best medical treatment in children with intracranial arterial occlusion stroke.
Methods: In this prospective registry study, 45 centres in 12 countries across Asia and Australia, Europe, North America, and South America reported functional outcomes for children aged between 28 days and 18 years presenting with arterial ischaemic stroke caused by a large-vessel or medium-vessel occlusion who received either endovascular thrombectomy plus best medical practice or best medical treatment alone.
Background And Purpose: Nerve cross-sectional area (CSA) is not constant over the human lifespan. The relationship between an increasing CSA and age has been described as a linear positive correlation, but few studies have found a linear decrease in nerve size with older age. The aim of the present study was to analyze the development of nerve CSA in a healthy population from early childhood to old age using high-resolution ultrasound.
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- Uremic neuropathy (UN) is a painful nerve problem that affects many people with severe kidney disease who get dialysis for a long time.
- This study looked at the size of different nerves in 10 patients with UN compared to 10 healthy people, using ultrasound and nerve tests.
- The results showed that patients with UN had some nerve damage, but their nerves didn't get bigger like in other studies; instead, one type of nerve was actually smaller, suggesting a loss of nerve fibers.