Publications by authors named "P D Samuel"
Background: Immune checkpoint inhibitors (ICIs) have moved to the frontline in recent years to manage upper gastrointestinal (UGI) tumors, such as esophageal and gastric cancers. This retrospective review sheds light on real-world data on ICI-treated UGI tumors to identify risk factors (clinical and pathological) impacting the outcome other than traditional biomarkers (programmed cell death ligand 1 (PD-L1) or microsatellite instability status).
Methods: Patients with UGI tumors who received at least one dose of ICI for stage IV or recurrent disease between January 1, 2015, and July 31, 2021, at The Ohio State University were included in the study.
The rapid global adoption of electric vehicles (EVs) necessitates the development of advanced EV charging infrastructure to meet rising energy demands. In particular, community parking lots (CPLs) offer significant opportunities for coordinating EVs' charging. By integrating energy storage systems (ESSs), renewable energy sources (RESs), and building prosumers, substantial reductions in peak load and electricity costs can be achieved, while simultaneously promoting environmental sustainability.
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- Harmful algal blooms caused by cyanobacteria pose risks to ecosystems, the economy, and human health, with a focus on how nutrient introduction affects gene expression.
- Through mesocosm experiments, researchers discovered that adding nitrogen (specifically urea) resulted in longer-lasting blooms by enhancing key biological processes like photosynthesis and toxin production.
- The study highlights potential biomarkers for bloom longevity and sheds light on the mechanisms that allow cyanobacteria to thrive, which could aid in developing strategies to manage and mitigate these harmful blooms.
Background: Early discharge planning is important for safe, cost-effective, and timely hospital discharges. Patients with deconditioning are at risk for prolonged lengths of stay related to discharge needs. Functional mobility outcome measures are associated with discharge disposition.
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- Trillions of microbes in the human mouth act as a crucial organ, but there's a lack of understanding about oral microbiomes in underrepresented ethnic groups in the U.S. like Hispanics, Blacks, and Asians.
- The study uses advanced sequencing to examine bacterial communities in saliva and plaque from 26 healthy individuals in South Florida, a culturally diverse area.
- Findings reveal notable differences in microbial composition based on factors like mouth location, sex, and gingival health, underscoring the importance of including a diverse range of populations in oral microbiome research.