Developing Photoactive Coumarin-Caged -Hydroxysulfonamides for Generation of Nitroxyl (HNO).

Photoactive -hydroxysulfonamides photocaged with the (6-bromo-7-hydroxycoumarin-4-yl)methyl chromophore have been successfully synthesized, and the mechanisms of photodecomposition investigated for two of the compounds. Upon irradiation up to 97% of a diagnostic marker for (H)NO release, sulfinate was observed for the trifluoromethanesulfonamide system. In the absence of a species that reacts rapidly with (H)NO, (H)NO instead reacts with the carbocation intermediate to ultimately generate ()-BHC-oxime and ()-BHC-oxime.

Ventilation and Public Health: A Fraught History.

Since the beginning of the COVID-19 pandemic, a vigorous public health discussion has arisen over indoor air quality and ventilation. In popular press articles, bestselling books, and the US Environmental Protection Agency's recently announced Clean Air in Buildings Challenge, scholars and policy experts have claimed that improved ventilation systems can lead to better productivity and performance. By reevaluating those claims in light of the history of public health in Great Britain and the United States, we found that better ventilation has frequently been proposed as a cost-effective and nonintrusive means of improving health in institutions experiencing structural and environmental public health problems.

Practical considerations for using low-cost sensors to assess wildfire smoke exposure in school and childcare settings.

Background: More frequent and intense wildfires will increase concentrations of smoke in schools and childcare settings. Low-cost sensors can assess fine particulate matter (PM) concentrations with high spatial and temporal resolution.

Objective: We sought to optimize the use of sensors for decision-making in schools and childcare settings during wildfire smoke to reduce children's exposure to PM.

Physical and pharmacokinetic characterization of Soluvec™, a novel, solvent-free aqueous ivermectin formulation.

To describe application of the Quicksol™ solvent-free approach to solubilize ivermectin (IVM). Lyophilized IVM complexed with hydroxypropyl-β-cyclodextrin (HP-β-CD) was resolubilized in aqueous polysorbate-80, generating Soluvec™. Lyophilizate was examined by Fourier-transform infrared spectroscopy and differential scanning calorimetry; Soluvec, by dynamic light scattering.

Within-City Variation in Ambient Carbon Monoxide Concentrations: Leveraging Low-Cost Monitors in a Spatiotemporal Modeling Framework.

Background: Based on human and animal experimental studies, exposure to ambient carbon monoxide (CO) may be associated with cardiovascular disease outcomes, but epidemiological evidence of this link is limited. The number and distribution of ground-level regulatory agency monitors are insufficient to characterize fine-scale variations in CO concentrations.

Objectives: To develop a daily, high-resolution ambient CO exposure prediction model at the city scale.