Publications by authors named "P D Ratnayake"
Article Synopsis
- This case report describes the first documented instance of a child having both mitochondrial encephalomyopathy (a condition affecting muscles and the brain) and nemaline myopathy (a muscle disorder), highlighting their coexistence.
- An 11-year-old Sri Lankan boy, previously healthy, experienced acute neurological symptoms, elevated lactate levels, and imaging results indicative of an acute brain infarction, leading to genetic testing that confirmed both conditions.
- The child's treatment included supportive care, antiepileptics, and supplements, with ongoing monitoring, underscoring the importance of genetic diagnosis for effective management and family counseling.
Article Synopsis
- Pyruvate carboxylase deficiency is a rare genetic condition affecting the enzyme that converts pyruvate to oxaloacetate, leading to three clinical phenotypes: neonatal type A, infantile type B, and a benign type C.
- This case series documents three Sri Lankan neonates, including two siblings, who exhibited respiratory distress at birth, with one sibling showing typical signs of type B and the other exhibiting unique characteristics of type A.
- The study emphasizes the importance of quick lab tests in newborns with breathing difficulties and metabolic issues for better management and family support, urging for more research on the overlapping symptoms of the different phenotypes.
Inflammation-derived oxidative stress is postulated to contribute to neuronal damage leading to poor clinical outcomes in Acute Ischemic Stroke (AIS). We aimed to investigate the association between serum levels of selected cytokines (IL-1β, IFN-γ, IL-4), and vitamin D in ischemic stroke progression, and their accuracy in predicting AIS prognosis, among Sri Lankans. We compared 60 AIS patients admitted in 4 phases post-stroke onset (<6 h; 6-24 h; 24-48 h; 48-96 h; n = 15/phase), with 15 age- and sex-matched controls.
View Article and Find Full Text PDFIn current clinical practices related to orthopedics, dental, and cardiovascular surgeries, a number of biomaterial coatings, such as hydroxyapatite (HAp), diamond-like carbon (DLC), have been used in combination with metallic substrates (stainless steel, Ti6Al4V alloy, etc.). Although SiBCN coatings are widely explored in material science for diverse applications, their potential remains largely unexplored for biomedical applications.
View Article and Find Full Text PDF