Publications by authors named "P D Mullins"
The use of sequential proton magnetic resonance spectroscopy (MRS) to follow glutamate and gamma-aminobutyric acid (GABA) changes during functional task-based paradigms, functional MRS (fMRS), has increased. This technique has been used to investigate GABA dynamics during both sensory and behavioural tasks, usually with long 'block design' paradigms. Recently, there has been an increase in interest in the use of short stimuli and 'event-related' tasks.
View Article and Find Full Text PDFHerein, we describe the design and synthesis of γ-secretase modulator (GSM) clinical candidate PF-06648671 () for the treatment of Alzheimer's disease. A key component of the design involved a 2,5--tetrahydrofuran (THF) linker to impart conformational rigidity and lock the compound into a putative bioactive conformation. This effort was guided using a pharmacophore model since crystallographic information was not available for the membrane-bound γ-secretase protein complex at the time of this work.
View Article and Find Full Text PDFBackground: Functional MRS (fMRS) is a technique used to measure metabolic changes in response to increased neuronal activity, providing unique insights into neurotransmitter dynamics and neuroenergetics. In this study we investigate the response of lactate and glutamate levels in the motor cortex during a sustained motor task using conventional spectral fitting and explore the use of a novel analysis approach based on the application of linear modelling directly to the spectro-temporal fMRS data.
Methods: fMRS data were acquired at a field strength of 3 Tesla from 23 healthy participants using a short echo-time (28ms) semi-LASER sequence.
Article Synopsis
- Commercially available HS-SPME fibers have been used to extract pesticides and polychlorinated biphenyls from alpine lake water, but analyte recovery related to concentration and storage time hasn't been thoroughly studied.
- Seven chlorinated pollutants were detected, but recovery rates varied significantly and could lead to underestimating actual contaminant levels in field samples.
- Of the 54 compounds analyzed, significant concentrations of several chlorinated pesticides were found, indicating a need for standardized recovery evaluation methods for accurate field analyses.
Objective: The objective of the study was to determine the associations of depression and anxiety with chronic pain among U.S. adults.
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