Publications by authors named "P D Morris"
Rheumatic heart disease remains prevalent in some regions of Australia and New Zealand. Echocardiography is the gold standard for detection and diagnosis using the 2023 World Heart Federation guidelines. The guidelines describe specific features of mitral and aortic valve morphology and define pathological regurgitation associated with RHD.
View Article and Find Full Text PDFThe objective of this study is to identify, examine, and map the literature on infection prevention and control (IPAC) education and training for visitors to long-term care (LTC) homes. Visitor restrictions during infectious outbreaks in LTC homes aim to reduce virus transmission to vulnerable residents. The COVID-19 pandemic highlighted the negative impacts of such restrictions, prompting the need for IPAC education for visitors.
View Article and Find Full Text PDFBackground: There are no approved oral disease-modifying treatments for Alzheimer's disease (AD).
Objectives: The objective of this study was to assess efficacy and safety of blarcamesine (ANAVEX®2-73), an orally available small-molecule activator of the sigma-1 receptor (SIGMAR1) in early AD through restoration of cellular homeostasis including autophagy enhancement.
Design: ANAVEX2-73-AD-004 was a randomized, double-blind, placebo-controlled, 48-week Phase IIb/III trial.
Article Synopsis
- The study explored the effects of a specific enzyme (FAEA) expressed in maize that targets the apoplast, focusing on its activity during the late stages of plant senescence and after storing the plant material.
- FAEA levels increased until the reproductive (R) stage but dropped during full leaf senescence (R+), while the enzyme remained stable even after six months of cold storage.
- The research found that FAEA expression led to decreased cell wall components like ferulates and improved the breakdown (saccharification) of plant material by enzymes, making it easier to extract sugars at later development stages.