Purified JC virus T antigen derived from insect cells preferentially interacts with binding site II of the viral core origin under replication conditions.

The human polyomavirus JC virus (JCV) establishes persistent, asymptomatic infections in most individuals, but in severely immunocompromised hosts it may cause the fatal demyelinating brain disease progressive multifocal leukoencephalopathy. In cell culture JCV multiplies inefficiently and exhibits a narrow host range. This restricted behavior occurs, in part, at the level of DNA replication, which is regulated by JCV's multifunctional large tumor protein (TAg).

Silver-coated nylon fiber as an antibacterial agent.

A blend of nylon fiber and silver-coated nylon fiber (the latter known as X-static) was used in these experiments. This fiber was bactericidal when bacteria were exposed to it directly or to an extract derived from its prior incubation in salt solution. At ambient temperatures, a rapid exponential decrease of survival occurred, usually after a delay of approximately 1 h.

Body composition, physical work capacity and physical activity habits at 18-month follow-up of middle-aged women participating in an exercise intervention program.

Thirty-six sedentary women (29-47 yr) participated in a 12-week, 4-d/week physical conditioning program (CP) involving 15-25 min/d of walking/jogging at a heart rate corresponding to 75 percent of aerobic capacity (VO2max). Twenty-three were classified obese (O, greater than 30 percent body fat, mean = 38 percent) and 13 normal (N, less than 30 percent body fat, mean = 25 percent). Significant post-CP changes included increased VO2max and decreased body fat.

Mortality related to cardiovascular disease and diabetes mellitus in a modernizing population.

Excessive adiposity is associated with elevated rates of middle-aged mortality, particularly that related to cardiovascular disease (CVD) and diabetes mellitus (DM). One purpose of this study was to determine whether the population of American Samoa demonstrated the expected elevation of mortality rates related to these two causes. Accordingly for all American Samoan death records (N = 1588) during the period 1962-74, both crude and age-standardized rates were calculated and interpopulation comparisons of DM and CVD were made.