Publications by authors named "P D Josephy"
Article Synopsis
- Gastrointestinal stromal tumors (GISTs) are tumors that come from specific cells in the gut and are primarily caused by certain genetic mutations; surgical removal is the best option for localized cases, while targeted drug therapies are the standard for management.
- Recent advances in understanding GISTs have led to updates in treatment strategies, but disparities in care exist across Canada due to its provincial healthcare system, highlighting the need for standardized guidelines.
- A panel of 20 experienced Canadian physicians from various specialties reviewed literature on GISTs to create a consensus on management practices, covering key topics like molecular profiling and multidisciplinary care to improve consistency in treatment across the country.
Tartrazine (E102, FD&C Yellow 5) is a vibrant yellow azo dye added to many processed foods. The safety of this ubiquitous chemical has not been fully elucidated, and it has been linked to allergic reactions and ADHD in some individuals. In our study, bacterial species isolated from human stool decolourised tartrazine and, upon exposure to air, a purple compound formed.
View Article and Find Full Text PDFObjectives: We set out to survey the capacities of bacterial isolates from the human gut microbiome to reduce common azo food dyes in vitro.
Methods: A total of 206 strains representative of 124 bacterial species and 6 phyla were screened in vitro using a simple azo dye decolorization assay. Strains which showed azoreductive activity were characterized by studies of azoreduction kinetics and bacterial growth.