Publications by authors named "P D Genova-Kalou"
Article Synopsis
- * Overall, 29.7% of students tested positive for infection markers, with Stara Zagora students showing higher rates (33.6%) compared to Sofia students (23%).
- * Higher seropositivity was found in male students (32.8%) compared to females (16.0%), highlighting the need for improved safety protocols and infection control in veterinary training programs.
Article Synopsis
- Monkeypox (mpox) is currently the leading zoonotic disease caused by the orthopoxvirus, with unusual transmission patterns recently observed outside of endemic regions.
- A study was conducted on 181 clinical samples from 42 Bulgarian patients to investigate the presence of monkeypox virus (MPXV) and other orthopoxvirus (OPXV) DNA.
- The results showed MPXV DNA in 23 samples and OPXV DNA in 20 samples, with the highest detection rates in vesicular contents and respiratory secretions, indicating that the virus can persist in various bodily fluids for more than two weeks post-infection.
Given the medical and social significance of infection, timely and reliable diagnosis of the disease is required. The traditional invasive and non-invasive conventional diagnostic techniques have several limitations. Recently, opportunities for new diagnostic methods have appeared based on the recent advance in the study of outer membrane proteins and their identified receptors.
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- Chemiluminescence tests showed that SARS-CoV-2 N and S proteins can significantly suppress oxidation by reactive oxygen species (ROS) at different pH levels.
- Both viral proteins exhibited antioxidant capabilities, performing better than albumin in neutral environments and matching its effectiveness at physiological pH.
- These findings suggest that the viral proteins may not contribute to oxidative stress during infection, potentially serving as an evolutionary self-defense mechanism against host immune responses.
One of the first clinical observations related to COVID-19 identified hematological dysfunctions. These were explained by theoretical modeling, which predicted that motifs from SARS-CoV-2 structural proteins could bind to porphyrin. At present, there is very little experimental data that could provide reliable information about possible interactions.
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