Allocolchicines─Synthesis with Electro-organic Key Transformations.

The naturally occurring colchicine and allocolchicines in the meadow saffron are potentially active ingredients for cancer therapy. A concise protocol for the sustainable synthesis of allocolchicines using up to two electro-organic key transformations is demonstrated. This straightforward synthesis of -acetylcolchinol methyl ether in a five-step protocol was adopted using protecting groups to enable access to -acetylcolchinol and the phosphate derivative ZD6126.

Mo-Based Oxidizers as Powerful Tools for the Synthesis of Thia- and Selenaheterocycles.

A highly efficient synthetic protocol for the synthesis of thia- and selenaheterocycles has been developed. By employing a MoCl -mediated intramolecular dehydrogenative coupling reaction, a broad variety of structural motifs was isolated in yields up to 94 %. The electrophilic key transformation is tolerated by several labile moieties like halides and tertiary alkyl groups.

Mild, Fast, and Easy To Conduct MoCl-Mediated Dehydrogenative Coupling Reactions in Flow.

A convenient and straightforward approach to performing oxidative coupling reactions in flow is presented. A collection of electron-rich benzene derivatives was subjected to this protocol, and the distinct utility of molybdenum pentachloride (MoCl) is established. Using this unexplored protocol, biphenyls could be obtained in 21-91% isolated yield.

Active Molybdenum-Based Anode for Dehydrogenative Coupling Reactions.

A new and powerful active anode system that can be operated in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) has been discovered. In HFIP the molybdenum anode forms a compact, conductive, and electroactive layer of higher-valent molybdenum species. This system can replace powerful but stoichiometrically required Mo reagents for the dehydrogenative coupling of aryls.

Modular Approach to 9-Monosubstituted Fluorene Derivatives Using Mo(V) Reagents.

Oxidative coupling using molybdenum(V) reagents provides fast access to highly functionalized 9-monosubstituted fluorenes. This synthetic approach is highly modular, is high yielding, and tolerates a variety of labile moieties, e.g.