Revealing 'Eha: A Qualitative Project on Historical Trauma Experiences Among Wāhine.

Historical trauma has been established as a determinant of health among all Hawaiians, but limited research exists on how Wāhine (Native Hawaiian women) uniquely experience historical trauma. A phenomenological qualitative study was conducted to primarily understand how historical trauma, trauma response, and the transmission and modes of intergenerational trauma intersect with sexism and patriarchy among contemporary Wāhine, as described in the Historical Trauma Conceptual Model. With partnership and approval of the Waimānalo Pono Research Hui, interviews were conducted with 13 Wāhine from various generations in Hawai'i.

Alzheimer's disease-specific transcriptomic and epigenomic changes in the tryptophan catabolic pathway.

Background: Neurodegenerative disorders, including Alzheimer's disease (AD), have been linked to alterations in tryptophan (TRP) metabolism. However, no studies to date have systematically explored changes in the TRP pathway at both transcriptional and epigenetic levels. This study aimed to investigate transcriptomic, DNA methylomic (5mC) and hydroxymethylomic (5hmC) changes within genes involved in the TRP and nicotinamide adenine dinucleotide (NAD) pathways in AD, using three independent cohorts.

The full picture of people's realities must be considered to deliver better diets for all.

Efforts to address poor-quality diets have stepped up considerably in recent years, but the problem of inadequate, unhealthy, unsustainable and unequal diets persists. Here we argue that to get policies and interventions working more effectively and equitably, a fresh approach is needed-one that considers the full picture of people's realities. People's realities interact to shape the way people respond to and engage with policies and interventions, thereby influencing their impact, particularly, albeit not only, on dietary inequalities.

Intellectual humility is reliably associated with constructive responses to conflict.

Conflict is a ubiquitous, but potentially destructive, feature of social life. In the current research, we argue that intellectual humility-the awareness of one's intellectual fallibility-plays an important role in promoting constructive responses and decreasing destructive responses to conflict in different contexts. In Study 1, we examine the role of intellectual humility in interpersonal conflicts with friends and family members.