Publications by authors named "P D Christensen"
Background: Transanal irrigation is a well-established minimally invasive therapy that addresses symptoms of both constipation and incontinence. The therapy has been extended from just neurogenic bowel dysfunction patients to those with disorders of brain-gut interaction and postsurgical conditions.
Aim: To summarized the literature on transanal irrigation and update the contraindication profile.
Background And Purpose: The prevalence of sequelae following rectal cancer (RC) treatment is high. We investigate the prevalence and temporal change in sexual dysfunction among male RC patient, along with their counselling and treatment needs and associations between sexual dysfunction and clinical factors. Patient/materials and methods: Patient-reported outcome measures were completed 3 and 12 months after RC surgery.
View Article and Find Full Text PDFBackground And Purpose: The gold standard when treating muscle-invasive bladder cancer (MIBC) is radical cystectomy (RC), a procedure that holds the potential to affect the function of several pelvic organs, causing an impact on the patient's Quality of Life (QoL). Knowledge of the late effects following bladder cancer and treatment with RC is sparse. The aim is to describe the incidence of late effects and to investigate the impact on QoL.
View Article and Find Full Text PDFBackground: The cornerstone of low anterior resection syndrome (LARS) treatment is self-management, which requires patient engagement. Colorectal surgeons and nurses may use patient-generated health data (PGHD) to help guide patients in their use of self-management strategies for LARS. However, the perspectives of LARS experts on the use of PGHD remain largely unexplored.
View Article and Find Full Text PDFArticle Synopsis
- Bacterial membranes are influenced by various evolutionary factors, with the enzyme MprF playing a crucial role in modifying membrane lipids.
- MprF synthesizes lysyl-phosphatidylglycerol (Lys-PG) and a new lipid, lysyl-glucosyl-diacylglycerol (Lys-Glc-DAG), prompting further investigation of MprF's substrate specificity in other bacteria.
- Using protein sequence analysis and machine learning, researchers discovered additional MprF products and the presence of diglucosyl-diacylglycerol (Glc-DAG) as a new substrate, highlighting the enzyme’s evolutionary significance across different bacterial species.