Prospective Home-use Study on Non-invasive Neuromodulation Therapy for Essential Tremor.

Highlights: This prospective study is one of the largest clinical trials in essential tremor to date. Study findings suggest that individualized non-invasive neuromodulation therapy used repeatedly at home over three months results in safe and effective hand tremor reduction and improves quality of life for many essential tremor patients.

Background: Two previous randomized, controlled, single-session trials demonstrated efficacy of non-invasive neuromodulation therapy targeting the median and radial nerves for reducing hand tremor.

An Acute Randomized Controlled Trial of Noninvasive Peripheral Nerve Stimulation in Essential Tremor.

Objective: To evaluate the safety and effectiveness of a wrist-worn peripheral nerve stimulation device in patients with essential tremor (ET) in a single in-office session.

Methods: This was a randomized controlled study of 77 ET patients who received either treatment stimulation (N = 40) or sham stimulation (N = 37) on the wrist of the hand with more severe tremor. Tremor was evaluated before and immediately after the end of a single 40-minute stimulation session.

Comparison of an Electronic Glycemic Management System Versus Provider-Managed Subcutaneous Basal Bolus Insulin Therapy in the Hospital Setting.

Background: American Diabetes Association (ADA) guidelines recommend a basal bolus correction insulin regimen as the preferred method of treatment for non-critically ill hospitalized patients. However, achieving ADA glucose targets safely, without hypoglycemia, is challenging. In this study we evaluated the safety and efficacy of basal bolus subcutaneous (SubQ) insulin therapy managed by providers compared to a nurse-directed Electronic Glycemic Management System (eGMS).

Large Format Surface-Enhanced Raman Spectroscopy Substrate Optimized for Enhancement and Uniformity.

Gratings have been widely investigated both theoretically and experimentally as surface-enhanced Raman spectroscopy (SERS) substrates, exhibiting, under appropriate circumstances, increased far-field extinctions and near-field intensities over those of an appropriately equivalent number of isolated particles. When the grating order transitions from evanescent to radiative, narrow resonance peaks are observed in the extinction spectrum whose properties can be manipulated by controlling the grating's geometric parameters. Here we report the application of the architectural principles of grating fabrication using a square two-dimensional array of gold-coated nanostructures that achieves SERS enhancements of 10(7) uniformly over areas of square centimeters.