Publications by authors named "P D Castaneda-Martinez"

This article reports the experience of the largest pediatric liver transplant (LT) program in México. Between June 1998 and May 2011, 76 LT were performed in 74 recipients, including 80% cadaveric-whole organ grafts and 20% segmental grafts, 12% of those coming from live donors and 8% from cadaver reduced donors. The most common indication for LT was biliary atresia (43%), followed by metabolic disorders (13%) and fulminant hepatitis (12%).

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Introduction: Early mortality in pediatric patients after liver transplantation (30 days) may be due to surgical and anesthetic perioperative factors.

Objective: To identify anesthetic risk factors associated with early mortality in pediatric patients who undergo liver transplantation (OLT).

Materials And Methods: This retrospective study of all patients who underwent a deceased or living donor liver transplantation evaluated demographic variables of age, weight, gender, degree of malnutrition, and etiology, as well as qualitative variables of anesthesia time, bleeding, massive transfusion, acid-base balance, electrolyte and metabolic disorders, as well as graft prereperfusion postreperfusion characteristics.

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Pediatric liver transplantation has evolved over the last two decades into an effective and widely accepted therapy for infants and children. Currently, these high-risk patients achieve 85 to 90% one-year patient survival and an excellent quality of life. This paper reviews the special features of the pediatric recipient, the surgical innovations developed to be able to offer them a transplant (reduced size, live donor, split, and auxiliary partial transplantation), the most significant issues in anesthetic, immunosuppressive and postoperative care in children, as well as a global picture of the results.

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Article Synopsis
  • OLT has been challenging to develop in Mexico, but a pediatric liver transplant program conducted between June 1998 and March 2004 performed 35 transplants with promising outcomes.
  • Most recipients were infants or toddlers, and while there were some complications, overall patient survival rates were encouraging, especially in the later cohort (1-year survival of 91.6%).
  • This program achieved significant milestones, including the first successful living donor liver transplant and the first simultaneous liver-kidney transplant in a child in Mexico, highlighting its feasibility and success compared to international standards.
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