Publications by authors named "P D Bianco"
Background: Intraoperative ultrasound-guided breast-conserving surgery guarantees real-time direct visualization of tumor and resection margins. We compared surgical, oncologic, and cosmetic outcomes between intraoperative ultrasound-guided breast-conserving surgery and traditional (palpation- or wire-guided) surgery across all breast cancer lesion types.
Methods: This prospective observational cohort study was conducted at the Veneto Institute of Oncology between January 2021 and October 2022.
Background And Aim: The aim of the present study was to evaluate the prevalence and to identify the independent predictors of multi-drug resistance among a cohort of patients admitted to emergency department for urinary tract infections (UTI), and to assess the impact of antimicrobial resistance on the clinical outcomes.
Methods: We conducted a prospective multicentre study enrolling all adult patients admitted to one of the eight emergency departments participating in the study with a microbiologically confirmed diagnosis of UTI from February 2023 to July 2024. The primary outcome evaluated was 30-day mortality; secondary outcomes included 7-day mortality and clinical response.
An integrated picture of the structural pathways controlling the heart performance.
Proc Natl Acad Sci U S A
December 2024
The regulation of heart function is attributed to a dual filament mechanism: i) the Ca-dependent structural changes in the regulatory proteins of the thin, actin-containing filament making actin available for myosin motor attachment, and ii) the release of motors from their folded (OFF) state on the surface of the thick filament allowing them to attach and pull the actin filament. Thick filament mechanosensing is thought to control the number of motors switching ON in relation to the systolic performance, but its molecular basis is still controversial. Here, we use high spatial resolution X-ray diffraction data from electrically paced rat trabeculae and papillary muscles to provide a molecular explanation of the modulation of heart performance that calls for a revision of the mechanosensing hypothesis.
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- Recent genome-wide association studies (GWASs) have discovered various single nucleotide polymorphisms (SNPs) that individually have a minimal impact on melanoma risk, but when combined, they can significantly improve predictions through a polygenic risk score (PRS).
- Researchers genotyped 270 melanoma patients who had negative genetic tests for high/medium-penetrance genes to develop a PRS model based on 57 SNPs, revealing a substantially higher average PRS in melanoma cases compared to controls.
- The study found that the mean PRS was notably higher for patients with multiple primary melanoma compared to those with a single case, indicating that the PRS could help identify high-risk individuals for more intensive monitoring.
Background: Antibody-mediated rejection is a significant cause of kidney transplant failure. Recent studies have shown that the MHC class I gene influences the transplantation outcome. However, the role of the primary receptor, NKG2D, has yet to be explored.
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