Irradiated Homologous Costal Cartilage Grafts in Complex Functional Septorhinoplasty.

Optimal results in complex nasal reconstruction, particularly in the context of post-traumatic and revision septorhinoplasty, often require the use of cartilage grafts to provide additional structural support to the nose. While autologous costal cartilage (ACC) has been traditionally used, this can be limited by donor site morbidity, increased operative time, and in some cases, lack of suitable cartilage for grafting. There has been a trend towards using irradiated homologous costal cartilage (IHCC) as an alternative source of graft material.

Facile construction of polyoxometalate-polymer hybrid nanoparticles with pH/redox dual-responsiveness.

Responsive nanomaterials have emerged as promising candidates for advanced drug delivery systems (DDSs), offering the potential to precisely target disease sites and enhance treatment efficacy. To fulfil their potential, such materials need to be engineered to respond to specific variations in biological conditions. In this work, we present a series of pH/redox dual-responsive hybrid nanoparticles featuring an amphiphilic shell polymer and a pH-responsive core polymer.

Highly selective organo-gallium hydroxamate mediated inhibition of antibiotic resistant .

Five complexes of gallium derived from hydroxamic acids have been synthesised, characterised, and their anti-bacterial activity and mammalian cell toxicity established. These are three metal-organic complexes; [Ga(BPHA)] 1, [Ga(BHA-)] 2, [Ga(SHA-)(SHA-)] 3, and two heteroleptic organometallic complexes [GaMe(BPHA)] 4, and [GaMe(BHA-)] 5, along with the iron complex [Fe(BPHA)] 6 (BPHA-H = -benzoyl--phenylhydroxamic acid, BHA-H = phenylhydroxamic acid, and SHA-H = salicylhydroxamic acid). Solid-state structures of 1, 4-6 were identified by single-crystal X-ray crystallography.