Outcomes in pregnancies with a confined placental mosaicism and implications for prenatal screening using cell-free DNA.

Purpose: To assess the association between confined placental mosaicism (CPM) and adverse pregnancy outcome.

Methods: A retrospective cohort study was carried out evaluating the outcome of pregnancies with and without CPM involving a rare autosomal trisomy (RAT) or tetraploidy. Birthweight, gestational age at delivery, fetal growth restriction (FGR), Apgar score, neonatal intensive care admission, preterm delivery, and hypertensive disorders of pregnancy were considered.

Effect of intermittent convection movements on voltammogram and current transients.

The influence of intermittent convection movements on electrochemical voltammograms is investigated. When the bath temperature rises to 315 K, the voltammograms exhibit irregular plateaus that differ for independent voltammetry scans, even when the setup is maintained under exactly the same conditions. In this paper, we show that such behavior can be caused by convection movements that develop in the electrolytic cell as a consequence of velocity fluctuations, since no bubbles or regular convective patterns are observed at this temperature.

Chromosome 11 segmental paternal isodisomy in amniocytes from two fetuses with omphalocoele: new highlights on phenotype-genotype correlations in Beckwith-Wiedemann syndrome.

Background: The phenotypic variability in Beckwith-Wiedemann syndrome (BWS) reflects the genetic heterogeneity of the mechanism which by default leads to the deregulation of genes located at 11p15.5. Genotype-phenotype correlation studies have demonstrated an association between omphalocoele and CDKN1C/p57 mutations or hypermethylation.

Fast and slow degrees of freedom coupling two different reservoirs.

We considered a Hamiltonian system that can be described by two generalized variables. One of them relaxes quickly when the system is in contact with a heat bath at fixed temperature, while the second one, the slow variable, mimics the interaction of the system with another heat bath at a lower temperature. The coupling between these variables leads to an energy flow between the heat baths.