Therapeutical influence of vagus blockade on antigen-induced airway obstruction.

The influence of bilateral vagus blockade on airway resistance induced by allergen exposure, while aerosol was given, was tested on 3 dogs. The therapeutic effect of vagus blockade could be demonstrated, which showed to be in a same degree as its prophylactic effect demonstrated in experiences before.

[The "IgA secretory component complex" in bronchial mucus in patients with chronic obstructive lung disease under different therapy (author's transl)].

The concentration of "IgA secretory component complex" in the bronchial mucus was measured under different therapeutical influences. The "IgA secretory component complex" is a most important factor of the exogenous immunodefense. The formation of the "IgA secretory component complex" was independent from the age of the patients and from the intensity of their airway obstruction.

The effect of sympathicomimetics and anticholinergics on antigen-induced airway obstruction.

The prophylactic and therapeutic effects of a sympathicomimetic drug 1-(3,5-dihydroxy-phenyl)-2-([1-(4-hydroxy-benzyl)-ethyl]-amino)-ethanol-hydrobromide (fenoterol HBr, Berotec) and an anticholinergic drug (8r)-8-isorpopyl-3 alpha-[(+/-)-tropoyl-oxy]-1 alpha H,5 alpha H-tropanium-bromide (ipratropium bromide, Atrovent) were tested on a series of 13 boxer dogs, exposed to allergen challenge. The therapeutic and prophylactic influence showed to be similar for both substances. The effect on bronchoconstriction was not followed by a similar influence on arterial blood gas values.

Fatigue of airway obstruction during long-term exposure to allergen aerosol.

The response to prolonged antigen exposure and the potentiation of airway resistance increase to ACH challenge, after this exposure, were studied on sixteen boxer dogs. One group of animals presented fatigue to A.E.