Influence of Oleacein, an Olive Oil and Olive Mill Wastewater Phenolic Compound, on Longevity and Stress Resistance.

Oleacein, a bioactive compound of olive oil and olive mill wastewater, has one of the strongest antioxidant activities among olive phenolics. However, few reports explore the in vivo antioxidant activity of oleacein, with no clear identification of the biological pathway involved. Earlier studies have demonstrated a link between stress resistance, such as oxidative stress, and longevity.

Water in cosmetics and Caenorhabditis elegans as an alternative model for lifespan assessment.

Objective: Water, often considered a fundamental component of life, is the most commonly used ingredient in the formulation of dermocosmetic products, with waterless products being the exception. Dermocosmetic products can contain anywhere from 50% to 85% water, which contributes to their texture and specific characteristics. The chemical composition of water varies depending on its origin and can be categorized as highly mineralized or low mineralized.

[Resistance to BRAF inhibitors: A lesson from clinical observations].

The MAPK/ERK pathway is an essential intracellular signaling pathway. Its deregulation is involved in tumor transformation and progression. The discovery of activating mutations of BRAF in various cancers has opened new therapeutic avenues with BRAF protein kinase inhibitors.

Perception of pharmacy students toward opioid-related disorders and roles of community pharmacists: A French nationwide cross-sectional study.

: Community pharmacists are among the frontline health professionals who manage patients with an opioid-related disorder (ORD). Pharmacists frequently have a negative attitude toward these patients, which could have a negative impact on their management. However, education on ORD may improve the attitude of future healthcare professionals.