Publications by authors named "P Creo"
Article Synopsis
- Patients with Brugada syndrome (BrS) face dangerous heart rhythm issues, and diagnosing it can be tricky due to atypical ECG patterns and the limited detectability of genetic markers like SCN5A variants.
- A study screened plasma from 50 BrS patients and found that 90% had anti-NaV1.5 autoantibodies, which were absent in 94% of control participants, indicating these autoantibodies could be a reliable diagnostic tool.
- The presence of these autoantibodies not only affects sodium current density but also induces Brugada-like ECG changes in experimental models, suggesting an autoimmune aspect to BrS that should be considered along with genetic factors.
Article Synopsis
- * Maintaining a balance between ceramide and S1P is crucial to prevent endothelial dysfunction, which is a key trigger for atherosclerosis and is linked to higher oxidative stress levels.
- * Modulating the levels of ceramide and S1P could lead to new antioxidant therapies that may help prevent or slow down atherosclerosis, ultimately improving patient outcomes in coronary artery disease.
Article Synopsis
- - Brugada Syndrome (BrS) is a genetic heart condition that increases the risk of sudden cardiac death, and it's now thought to involve multiple genes rather than just one.
- - Research involving 42 BrS patients and 42 healthy individuals showed significant changes in gene expression and protein sialylation in the blood cells of those with BrS, linking these changes to the disease's symptoms.
- - The study suggests that disruptions in protein sialylation not only affect heart channels but also impact other body tissues, indicating potential biomarkers for diagnosing BrS.
Interleukin (IL)-33 is a member of the interleukin (IL)-1 family of cytokines linked to the development of inflammatory conditions and cancer in the gastrointestinal tract. This study is designed to investigate whether IL-33 has a direct effect on human gastric epithelial cells (GES-1), the human gastric adenocarcinoma cell line (AGS), and the gastric carcinoma cell line (NCI-N87) by assessing its role in the regulation of cell proliferation, migration, cell cycle, and apoptosis. Cell cycle regulation was also determined in ex vivo gastric cancer samples obtained during endoscopy and surgical procedures.
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