Publications by authors named "P Crafa"
Article Synopsis
- Gastrointestinal severe adverse events like ulceration and perforation have been linked to polystyrene sulfonate and sevelamer, especially in patients with chronic kidney disease, but the exact cause is unclear.* -
- A meta-analysis of existing research found that polystyrene sulfonate is significantly more likely to cause severe issues such as necrosis or perforation compared to sevelamer (p < 0.001).* -
- The findings indicate that while sevelamer may cause inflammation or ulceration, polystyrene sulfonate is more strongly associated with severe outcomes, including a higher risk of death (p < 0.001).*
Background: Proton pump inhibitors (PPIs) are currently the reference drugs for gastroesophageal reflux disease (GERD), but symptoms often recur after their withdrawal. Moreover, whether prokinetics or barrier drugs used alongside PPIs are more effective remains under debate.
Objectives: The aim of the study was to assess the efficacy of different therapeutic approaches to GERD treatment.
Hydrochloric acid is crucial in gastric physiology. In 1978 cimetidine, the first H2 antagonist of histamine receptors on the gastric parietal cell was introduced into therapy, inducing acid. Lasting the years, several studies focused on the potential relationship between inducing hypo-achlorhydria and risk of developing gastric cancer.
View Article and Find Full Text PDFInappropriate prescription of proton pump inhibitors (PPI) has been widely reported, often lacking initial exclusion of (HP) infection and evaluation of gastric functional status. The aim of this study was to evaluate the utility of gastric functional tests to define the acid output, as well as HP status, in order to better direct PPI therapy prescription. Dyspeptic patients without alarm symptoms from a primary care population were evaluated.
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