Publications by authors named "P Cos"

Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory tract infections in young children, elderly and immunocompromised patients worldwide. The RSV fusion (F) protein, which has 5-6 N-glycosylation sites depending on the strain, is a major target for vaccine development. Two to three of these sites are located in the p27 peptide, which is considered absent in virions.

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Mycobacterium abscessus (Mab) infections are challenging to treat due to high intrinsic drug resistance, comparable to multidrug-resistant tuberculosis. Treatments are extremely ineffective and based on a multi-drug regimen, resulting in low patient compliance. Consequently, the scientific community is urged to identify new and effective drugs to treat these infections.

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Article Synopsis
  • * This study introduces an antibacterial hydrogel coating utilizing polymyxin B (PMB) to inhibit bacterial adhesion, with thorough characterization of its properties and effectiveness against bacteria demonstrated over at least 8 days.
  • * The coating meets international cytocompatibility standards and shows potential for prolonged PMB release, laying the groundwork for future peptide-releasing formulations aimed at preventing VAP.
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Article Synopsis
  • Mab is a highly resistant pathogen that presents a serious threat to individuals with cystic fibrosis and other chronic lung diseases, comparable to multidrug-resistant tuberculosis.
  • Current treatment options involve long multidrug therapies, which are often ineffective, leading to high rates of treatment failure and mortality, highlighting the urgent need for new drug development.
  • The research focuses on creating stable double-reporter strains of Mab to streamline drug screening, allowing for efficient identification of potential treatments through high-throughput methods while maintaining the pathogen's original characteristics.
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The synthesis of an extensive series of new squaramides with high potential in treating drug-resistant tuberculosis employing the Liebeskind-Srogl cross-coupling reaction is presented. Using the protocol given and various substrates, we assessed the scope and limitations of our methodology and prepared an extensive range of desired compounds. Moreover, H NMR spectra in solution show the presence of two rotational conformers (rotamers) in special cases.

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