Publications by authors named "P Coronel Granado"

Primary malignancies of the central nervous system account for 2% of all cancers in adults and almost 15% in children under 15 years of age. The prognosis of brain anaplastic cancers and glioblastomas remains extremely poor, with devastating survival expectative, and new molecular markers and therapeutic targets are essential. Epigenetic changes constitute an extensive field for the development of new diagnostic and therapeutic strategies.

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Article Synopsis
  • Pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDAC), is a deadly cancer often diagnosed late, making treatment and prognosis challenging.* -
  • The study explored the prognostic value of RANK and RANKL proteins in relation to survival outcomes of 41 pancreatic cancer patients over 60 months.* -
  • It found that higher levels of RANK and RANKL are linked to poorer survival rates, suggesting potential targets for further research on treatment options.*
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Purpose: To elucidate if the differences found in the physico-chemical and rheological behaviour of Hyaluronic Acids result in different in vivo activity. For this purpose two Hyaluronic Acids (HA), HA-1 and HA-2, with similar molecular weight but different percentage of concentration variation, were compared through an osteoarthritis model.

Methods And Materials: Osteoarthritis was induced in white New Zealand rabbits by anterior cruciate ligament section.

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This study was carried out to study the safety and efficacy of a fixed dosage of sulodexide compared to adjusted dosages (INR) of acenocoumarol as secondary prophylaxis in patients with deep vein thrombosis (DVT) in lower limbs. An economic evaluation based on the criteria of use in normal clinical practice was also performed. One hundred and fifty patients of both sexes were included, all over 18 years of age and diagnosed with proximal DVT of the lower limbs by color echo-Doppler, and with clinical evolution of less than 1 month.

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