Publications by authors named "P Conforti"
After a stroke, the neurogenic response from the subventricular zone (SVZ) to repair the brain is limited. Microglia, as an integral part of the distinctive SVZ microenvironment, control neural stem / precursor cell (NSPC) behavior. Here, we show that discrete stroke-associated SVZ microglial clusters negatively impact the innate neurogenic response, and we propose a repository of relevant microglia-NSPC ligand-receptor pairs.
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- Huntington's disease (HD) leads to the degeneration of specific brain neurons, resulting in a mix of functional and dysfunctional cells, but the interactions between these cell types are not well understood.
- Researchers created brain organoids containing both healthy and HD cells, finding that HD organoids displayed neurodevelopmental issues and fewer GABAergic neurons compared to healthy ones.
- Healthy cells in mixed organoids helped to restore the identity and function of HD cells through direct interactions, suggesting that enhancing communication between different cell types could offer new treatment strategies for HD.
Wound healing of the central nervous system (CNS) is characterized by the classical phases of 'hemostasis', 'inflammation', 'proliferation', and 'remodeling'. Uncontrolled wound healing results in pathological scar formation hindering tissue remodeling and functional recovery in the CNS. Initial blood protein extravasation and activation of the coagulation cascade secure hemostasis in CNS diseases featuring openings in the blood-brain barrier.
View Article and Find Full Text PDFThis review focuses on ablative techniques for small renal masses (SRMs), including radiofrequency ablation (RFA), cryoablation (CA), microwave ablation (MWA), and irreversible electroporation (IRE), and discusses recurrence management. Through an extensive literature review, we outline the procedures, outcomes, and follow-up strategies associated with each ablative method. The review provides a detailed examination of these techniques-RFA, CA, MWA, and IRE-elucidating their respective outcomes.
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- The analysis introduces a food system indicator framework and monitoring architecture to assess food system changes related to global development and sustainability goals, focusing on five key themes: diets and health, environmental impact, livelihoods and equity, governance, and resilience.
- A total of 50 indicators were developed through a consultative process, ensuring coverage for each theme, which serves as a baseline for evaluating global food systems.
- While every country shows positive outcomes in certain areas, no country excels across all domains, indicating room for improvement towards achieving healthy, sustainable, and equitable food systems by 2030.