Publications by authors named "P Compagnon"
Transjugular intrahepatic portosystemic shunt (TIPS) reduces portal hypertension complications. Its impact on hepatocellular carcinoma (HCC) remains unclear. We evaluated 42,843 liver transplant candidates with HCC from the Scientific Registry of Transplant Recipients (2002-2022).
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- A new study evaluated long-term outcomes of liver transplants from donors treated with hypothermic oxygenated machine perfusion (HOPE) across 22 European centers, involving 1,202 transplant cases from 2012 to 2021.
- The study showed high 1-, 3-, and 5-year death-censored graft survival rates for both donation after brain death (DBD) and donation after circulatory death (DCD), with low rates of primary non-function (PNF) and ischaemic cholangiopathy (IC).
- The findings indicate that HOPE treatment effectively improves liver transplant outcomes, regardless of the donor's risk profile, and supports its incorporation into routine clinical practice.
Background: Pancreatic islet transplantation for type 1 diabetes mellitus (T1DM) is efficacious in supressing severe hypoglycaemic episodes (SHE) and restoring glycaemic regulation, which are both pivotal in increasing health-related quality of life (HRQoL). Therefore, a systematic assessment of reports detailing HRQoL outcomes is warranted to better understand the benefits of islet transplantation. To this end, we performed a systematic review of the literature to assess the impact of islet transplantation on HRQoL in individuals with T1DM, whether as a standalone procedure (ITA) or following renal transplantation (IAK).
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- - Diabetes is a chronic disease with rising prevalence and often leads to psychological issues that may need specific treatment strategies.
- - Pancreas or islet transplantation is a potential treatment for some patients with type 1 diabetes who have unstable conditions or complications.
- - The article explores the psychological challenges faced by diabetic patients undergoing transplantation and emphasizes the importance of having a liaison psychiatrist involved in their care.
Article Synopsis
- The study identifies lysophosphatidylinositols (lysoPIs) as key lipid species that increase in the blood of prediabetic mice and diabetic patients, linked to the loss of pancreatic β-cells.
- Increased lysoPIs correlate with markers of poor glycemic control, such as HbA1c and fasting glycemia, but not with insulin resistance or obesity in humans with type 2 diabetes.
- The research indicates that lysoPIs enhance insulin secretion from pancreatic cells, suggesting a potential role in mitigating diabetes-related β-cell dysfunction.