GPx1 deficiency confers increased susceptibility to ferroptosis in macrophages from individuals with active Crohn's disease.

Intestinal cell death is a defining feature of Crohn's disease (CD), a major form of inflammatory bowel disease. The focus on this aspect of enteric inflammation has mainly been on epithelial cells, while other cell types such as stromal and myeloid cells have received less attention. Hypothesising that decreased macrophage viability in an oxidative environment could be a contributing factor to the pathophysiology of CD, we found that monocyte-derived macrophages from individuals with active CD (but not those in clinical disease remission) have increased sensitivity to cell death induced by HO.

Proximity to inlet channel drives spatial variation in sediment carbon across a lagoonal seagrass meadow.

Seagrass meadows can be sinks for organic carbon, but estimates of global organic carbon stocks are complicated by substantial spatial variability in organic carbon burial observed within meadows. To improve estimates of organic carbon burial in seagrass meadows, it is necessary to understand the causes of the spatial heterogeneity. This study investigated relationships between spatial patterns in sediment organic carbon storage and accretion rates, hydrodynamics, and proximity to sources of organic carbon in a current-dominated Zostera marina Linnaeus meadow in Menemsha Pond, Massachusetts, USA.

Fantastic wetlands and why to monitor them: Demonstrating the social and financial benefit potential of methane abatement through salt marsh restoration.

Salt marsh restoration has the potential to reduce greenhouse gas emissions thereby providing an opportunity for blue carbon crediting, but implementation has been limited to date because of insufficient data and validation. In this paper, we demonstrate the potential scale of methane emissions that could be avoided if salinity-reducing impairments are mitigated by applying findings from six salt marsh restoration sites in Massachusetts combined with a previously demonstrated application of the salt marsh salinity-methane relationship. We used calculations of these avoided emissions to estimate the social benefit of salt marsh restoration by calculating avoided costs.

Travel surveillance uncovers dengue virus dynamics and introductions in the Caribbean.

Dengue is the most prevalent mosquito-borne viral disease in humans, and cases are continuing to rise globally. In particular, islands in the Caribbean have experienced more frequent outbreaks, and all four dengue virus (DENV) serotypes have been reported in the region, leading to hyperendemicity and increased rates of severe disease. However, there is significant variability regarding virus surveillance and reporting between islands, making it difficult to obtain an accurate understanding of the epidemiological patterns in the Caribbean.

Travel surveillance uncovers dengue virus dynamics and introductions in the Caribbean.

Dengue is the most prevalent mosquito-borne viral disease in humans, and cases are continuing to rise globally. In particular, islands in the Caribbean have experienced more frequent outbreaks, and all four dengue virus (DENV) serotypes have been reported in the region, leading to hyperendemicity and increased rates of severe disease. However, there is significant variability regarding virus surveillance and reporting between islands, making it difficult to obtain an accurate understanding of the epidemiological patterns in the Caribbean.