Publications by authors named "P Cogo"
Unlabelled: The objective of this study is to evaluate whether early hypoglycemia is an independent risk factor for 2-year cognitive (COG) impairment in small for gestational age (SGA) preterm infants with gestational age (GA) < 32 weeks. We retrospectively reviewed data of 1364 preterm infants with a GA 24-31 weeks. Infants were classified based on blood glucose concentrations within the first 6 h of life (HOL) as < or ≥ 40 mg/dL (Glyc < 40 and Glyc ≥ 40, respectively) and subsequently by birth weight z-score as SGA or appropriate for gestational age (AGA).
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- The study investigates how much fatty acids (FAs) are produced by human fetuses and how this relates to the fatty acids present in their mothers' blood at delivery.
- Researchers analyzed data from 39 mother-fetus pairs, noting significant correlations in specific fatty acid levels between mothers and fetuses, indicating reliance on maternal sources.
- Results show that while maternal DHA sources differed (algae vs. fish oil), the fetus contributes little to fatty acid production, highlighting the importance of maternal nutrition during pregnancy for fetal development.
Article Synopsis
- Fetal challenges, like exposure to viruses such as Zika, can affect infant brain development and psychological growth later in life.
- A study on juvenile rhesus monkeys exposed to Zika during pregnancy showed that while their decision-making remained consistent, their responses to negative emotions differed from unaffected peers.
- The findings indicate that Zika exposure may disrupt how the brain processes emotions and decision-making, potentially affecting long-term abilities in learning, memory, and emotional regulation.
CoQ (Coenzyme Q) is an essential fat-soluble metabolite that plays a key role in cellular metabolism. A less-known function of CoQ is whether it may act as a plasma membrane-stabilizing agent and whether this property can affect cancer development and progression. Here, we show that CoQ and its biosynthetic enzyme UBIAD1 play a critical role in plasmamembrane mechanical properties that are of interest for breast cancer (BC) progression and treatment.
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