Publications by authors named "P Cocuzza"
Purpose: To compare Italian use with current international guidelines and to evaluate oncological outcomes and toxicity patterns of adjuvant radiation therapy (RT) for endometrial cancer (EC) in Italian women.
Materials And Methods: To conduct a retrospective multicentre Italian study a large database was set up. Inclusion criteria were: accrual between 2010 and 2020, treatment with surgery, post-operative external beam RT (EBRT) and/or interventional radiotherapy (IRT) associated or not with adjuvant chemotherapy.
Background/aim: The present study aimed to investigate radiomics features derived from magnetic resonance imaging (MRI) in patients with locally advanced rectal cancer treated with neoadjuvant chemoradiotherapy (CRT).
Patients And Methods: We retrospectively evaluated data of 53 patients (32 males, 21 females) with T3/T4 or N+ rectal cancer who underwent MRI before and after CRT. Twenty-seven texture radiomics features were extracted from regions of interest, delimiting the tumor on T2-weighted images.
Article Synopsis
- The study compares radiotherapy activity volumes in Pisa during the COVID-19 pandemic (March 9 - May 31, 2020) to the same timeframe in 2019.
- A notable 18% decrease in first-time visits was observed in 2020, attributed to diagnosis delays and operating room closures.
- Despite these challenges, the hospital successfully treated all referred patients and minimized COVID-19 infections among staff and patients.
Purpose: To develop a videofluoroscopy-based predictive model of radiation-induced dysphagia (RID) by incorporating DVH parameters of swallowing organs at risk (SWOARs) in a machine learning analysis.
Methods: Videofluoroscopy (VF) was performed to assess the penetration-aspiration score (P/A) at baseline and at 6 and 12 months after RT. An RID predictive model was developed using dose to nine SWOARs and P/A-VF data at 6 and 12 months after treatment.
Article Synopsis
- Radiation therapy is a key treatment for head and neck squamous cell carcinomas (HNSCC), often combined with surgery or chemotherapy.
- Intensity-modulated radiation therapy (IMRT) has improved treatment efficacy by allowing precise targeting of tumors while minimizing damage to surrounding healthy tissues.
- Despite being historically considered low risk for radiation-induced nausea and vomiting (RINV), recent findings suggest that IMRT might actually increase these side effects, prompting a need for further research to understand the incidence and causes of RINV in HNSCC patients.