Publications by authors named "P Coccia"
The coronavirus disease 2019 (COVID-19) pandemic, instigated by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has profoundly impacted healthcare infrastructures around the globe. While children are usually asymptomatic or have mild symptoms, children with pre-existing kidney conditions require specialized attention. This pivotal report, championed by the International Pediatric Nephrology Association (IPNA), delivers precise and actionable recommendations tailored for pediatric patients with kidney ailments in this pandemic landscape.
View Article and Find Full Text PDFBackground: Shiga toxin-producing Escherichia coli-associated hemolytic uremic syndrome (STEC-HUS) is a severe condition mainly affecting children. It is one of the leading causes of acute kidney injury in the pediatric population. There is no established therapy for this disease.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on treating four children with FH antibody-mediated hemolytic uremic syndrome (HUS) using eculizumab, an alternative therapy, alongside immunosuppression instead of traditional treatments like plasmapheresis.
- In the review, patients displayed improvements in hematological signs and kidney function within weeks of starting eculizumab, with three of them discontinuing the treatment after six months without complications.
- The findings indicate that a short eculizumab regimen could effectively reverse severe symptoms and enhance kidney health, potentially with lower relapse risks when combined with immunosuppressive agents.
Article Synopsis
- Imerslund-Gräsbeck syndrome (IGS) is a rare genetic condition that leads to anemia and the body not absorbing vitamin B12 properly.
- A 23-month-old baby in Italy was diagnosed with IGS after showing serious health issues, but vitamin B12 treatment helped improve the situation.
- Genetic tests revealed two unusual changes in a specific gene, which are linked to the condition, and it's important to diagnose IGS early to avoid serious problems.