Publications by authors named "P Cimflova"
Background: Cerebrospinal fluid (CSF) loss in spontaneous intracranial hypotension (SIH) is accompanied by volume shifts between the intracranial compartments. This study investigated tricompartimental and longitudinal volume shifts after closure of a CSF leak.
Methods: Patients with SIH and suitable pre-therapeutic and post-therapeutic imaging for volumetric analysis were identified from our tertiary care center between 2020 and 2023.
Background: A third of endovascularly treated patients with stroke experience incomplete reperfusion (expanded Thrombolysis in Cerebral Infarction [eTICI] <3), and the natural evolution of this incomplete reperfusion remains unknown. We systematically reviewed the literature and performed a meta-analysis on the natural evolution of incomplete reperfusion after endovascular therapy.
Methods: A systematic review of MEDLINE, Embase, and PubMed up until March 1, 2024, using a predefined strategy.
Article Synopsis
- The study assessed how the quality of reperfusion affects clinical and radiological outcomes in patients from the ESCAPE NA1 trial.
- Researchers analyzed different reperfusion patterns using the expanded Treatment in Cerebral Infarction (eTICI) Scale to compare patient outcomes, including rates of good or excellent clinical recovery, symptomatic hemorrhage, and death.
- Results showed that higher reperfusion grades were linked to better clinical outcomes and lower mortality rates, regardless of how many attempts were needed to achieve them, or the speed of reperfusion.
Background: Distal occlusions associated with incomplete reperfusion (expanded Thrombolysis in Cerebral Infarction,
Methods: Retrospective registry analysis of patients undergoing endovascular therapy between July 2020 and December 2022, with available immediate post-interventional FPDCT and 24 hours follow-up perfusion imaging.
Article Synopsis
- The study examines the safety and effectiveness of intravenous tenecteplase compared to alteplase in treating patients with acute ischemic strokes in the posterior circulation.
- A post-hoc analysis of over 1,500 patients found no significant differences in outcomes between the two treatments in terms of recovery, symptomatic intracerebral hemorrhage, and mortality.
- Both medications showed similar rates of successful reperfusion and recanalization, suggesting that tenecteplase can be as effective as alteplase for this type of stroke without increased risks.