Publications by authors named "P Chitkara"
Article Synopsis
- The study identifies 169,197 fusion transcripts in various plant species, suggesting that these transcripts contribute to physiological processes beyond cancer, including stress responses and morphological traits.
- By analyzing various datasets, the researchers confirm the active translation of some fusion transcripts and explore how DNA sequence organization and chromatin structure influence their formation.
- The findings indicate that a large number of fusion events result from alternative splicing and that genes located near each other are more likely to fuse, with many fusion transcripts not being translated into proteins.
Fusion transcripts are formed when two genes or their mRNAs fuse to produce a novel gene or chimeric transcript. Fusion genes are well-known cancer biomarkers used for cancer diagnosis and as therapeutic targets. Gene fusions are also found in normal physiology and lead to the evolution of novel genes that contribute to better survival and adaptation for an organism.
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- Regulation of RNA stability and translation by RNA-binding proteins (RBPs) is important for gene expression, with the Musashi family (including Msi1 and Msi2) playing a key role, particularly in the heart where Msi2's function was previously unclear.
- This study confirmed the presence of Msi2 in adult mouse and rat hearts, identifying multiple isoforms of Msi2 expressed, and demonstrated that overexpression of these isoforms led to cardiac hypertrophy and heart failure in models.
- Additionally, increased Msi2 levels were linked to mitochondrial dysfunction, and it was found that the proteins Cluh and Smyd1 could counteract some of the damaging effects of Msi2, underlining Msi2
Lipid Transfer Proteins (LTPs) play a crucial role in synthesizing lipid barrier polymers and are involved in defense signaling during pest and pathogen attacks. Although LTPs are conserved with multifaceted roles in plants, these are not yet identified and characterized in . In this study, a genome-wide analysis of LTPs was executed and their physiochemical properties, biochemical function, gene structure analysis, chromosomal localization, promoter analysis, gene duplication, and evolutionary analysis were performed using tools.
View Article and Find Full Text PDFBackground & Aims: Previous studies have shown a potential association between nonalcoholic fatty liver disease (NAFLD) and some immune-mediated inflammatory diseases, such as rheumatoid arthritis (RA), but this association has not been analyzed systematically. Therefore, we aimed to perform a systematic review and meta-analysis to ascertain a pooled prevalence estimate of NAFLD among patients with RA to fill this gap in knowledge.
Methods: We conducted a literature search in PubMed, Embase, Web of Science, Scopus, and ProQuest, for observational studies published from inception to August 31, 2022, which reported prevalence of NAFLD in 100 or more adult (age, ≥18 y) patients with RA.