Publications by authors named "P Chheda"
Objective: To study the prevalence, clinical presentation, treatment, and follow-up of ocular (dermal) melanocytosis (ODM) and its association with choroidal melanoma (CM) in Asian Indian patients.
Methods: This was a retrospective case series of patients with ODM conducted in a quaternary eye care center.
Results: Of the total 1.
On-DNA carboxylic acids are important synthetic intermediates in the synthesis of DNA-encoded library (DEL) structures. Herein, we report an oxoammonium salt-mediated, room temperature, solution-phase oxidation of DNA-linked primary alcohols into carboxylic acids. This method exhibits a wide substrate scope, encompassing aliphatic, benzylic, and heterobenzylic alcohols, and is compatible with DEL encoding strategies.
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- DNA-encoded libraries (DELs) are important for discovering small-molecule drugs, but their chemical diversity is restricted to water-friendly reactions to keep DNA tags intact.
- A new workflow using DNA-cationic surfactant complexation allows DELs to operate in dry organic solvents, expanding the range of chemical reactions possible.
- The method is optimized for large-scale production in a 96-well format, facilitating screening and improvement of reactions suitable for DELs in non-aqueous environments.
Purpose: To report the clinical presentation, anterior segment optical coherence tomography features, treatment, and outcomes of ocular surface squamous neoplasia (OSSN) associated with pterygium.
Methods: Retrospective interventional series of 14 cases in a 28-month study period.
Results: OSSN was coexistent with pterygium ( = 14) in < 1% of all pterygia ( = 7384).