Publications by authors named "P Chedid"
Article Synopsis
- This study investigated the prevalence of type 2 diabetes (T2D) in Lebanon, focusing on its connection with inflammation and infection markers, using data from over 4,000 patients.
- The findings revealed that 17% of participants had T2D, with higher levels of C-reactive protein (CRP) and a significant association with factors like age, gender, and triglycerides.
- Additionally, urinary tract infections, particularly from E. coli, were the most common in a subgroup of patients, indicating a worrying trend in diabetes-related health issues in Lebanon.
Metformin (1,1-dimethylbiguanide hydrochloride) is the most commonly used drug to treat type II diabetic patients. It is believed that this drug has several other beneficial effects, such as anti-inflammatory and anticancer effects. Here, we wanted to evaluate the effect of metformin on the production of reactive oxygen species (ROS) by human macrophages.
View Article and Find Full Text PDFBackground And Objectives: Vascular Endothelial Growth Factor (VEGF) is an essential regulator of vascular biology. In addition to the well-established role in angiogenesis, circulating VEGF levels were found elevated in severely anemic patients, pointing out that anemia might affect the progression of angiogenesis in malignant and benign diseases through the alteration of VEGF levels. Ten single nucleotide polymorphisms (SNPs) in and other loci were shown to explain more than 50% of its circulating levels.
View Article and Find Full Text PDFBackground And Objective: Toll-like receptors (TLRs) are important components of the innate immune system, involved in establishing immunity to infections. Apart from being implicated in immunity, numerous studies have reported that many TLRs, including TLR2, are involved in the pathogenesis of cardiovascular diseases and their risk factors. Since rs1898830 is associated with TLR2-mediated cellular activation, we aimed to study its association with CVD risk factors, such as lipid levels and hypertension.
View Article and Find Full Text PDFRationale: Since identifying gender-specific genetic associations may have a significant impact on public health, we studied the interaction between rs2569190 in CD14 (cluster of differentiation 14) and gender in relation to the lipid traits in two independent populations.
Methods: We first tested the interaction in a discovery population (SFS, n = 956), then replicated it in an independent population (LGP, n = 460), followed by a meta-analysis (n = 1,416). Finally, stratification according to gender was conducted to test the association between rs2569190 and lipid traits.