Publications by authors named "P Chavanet"
Article Synopsis
- Cefepime/enmetazobactam is a new antibiotic duo effective against multidrug-resistant Enterobacterales, particularly strains producing OXA-48 enzymes, with potential use in treating hospital-acquired pneumonia.
- In a mouse study, combining cefepime with enmetazobactam significantly reduced bacterial levels in the lungs compared to treatment with either drug alone or with meropenem, especially against high-resistance strains.
- These findings suggest cefepime/enmetazobactam could be a promising alternative for tackling lung infections caused by resistant Enterobacterales, demonstrating better antibacterial activity than currently used treatments.
Carbapenem-resistant (CRAB) is an emerging cause of hospital-acquired pneumonia (HAP). Preclinical large models are warranted to predict the efficacy and the resistance profile of anti-infectives and mimic how they will be used in the human treatment of CRAB-HAP. Here we reported on the development of an experimental pneumonia model in immunocompromised rabbits, receiving a 48-h human-simulated regimen.
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- A study tested 15 bacterial strains to evaluate the effectiveness of combining amoxicillin and ceftriaxone.
- Results showed a synergy between the two antibiotics in 93% of cases using minimal inhibitory concentration strips and 80% using checkerboard methods.
- This combination could potentially be used as a new treatment option for listeriosis moving forward.
Objectives: Limited pharmacokinetics data support dalbavancin long-term use in off-label indications and the optimal dosing regimen is debated. We aimed to describe dalbavancin concentrations in an observational retrospective multicentre study.
Methods: Patients from 13 French hospitals, treated with 1500 mg doses of dalbavancin and for whom therapeutic drug monitoring was performed from June 2018 to March 2021 were included.
Methicillin-resistant (MRSE) contributes to a high percentage of orthopedic infections, and their treatment represents a huge challenge. The present study aimed to evaluate the efficacy of ceftaroline alone or combined with rifampin in a rat MRSE osteomyelitis model and the bone penetration of ceftaroline. A ceftaroline monotherapy showed a significant bacterial reduction in infected bones after a 7-day period of treatment.
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