Publications by authors named "P Chamouni"
Objectives: To assess the real-world efficacy and safety of recombinant factor IX albumin fusion protein (rIX-FP) in patients with hemophilia B (HB) in France.
Methods: Data on dosing frequency, weekly consumption, and bleeds before-and-after switching to rIX-FP, were collected from December 2021 to February 2024. Annualized (spontaneous) bleeding rates [A(s)BRs] were calculated only in patients on prophylaxis with a follow-up ≥ 6 months.
Surgery in rare bleeding disorders: the prospective MARACHI study.
Res Pract Thromb Haemost
October 2023
Article Synopsis
- Bleeding risk assessment before surgery in patients with rare inherited bleeding disorders is complex, despite established bleeding scores and clotting factor measurements.
- A study involving 178 patients with low coagulation levels analyzed how hemostasis experts managed bleeding risks during 207 surgical procedures and the resulting bleeding outcomes.
- Results showed that most surgeries were performed without factor replacement, particularly in mild deficiencies, and indicated that factor levels and the type of surgery are more critical for deciding perioperative treatment than bleeding scores.
Article Synopsis
- The TRANSHEMO project aimed to investigate how well adolescents and young adults with severe haemophilia adhere to healthcare, particularly during their transition from pediatric to adult care, viewing adherence as a key indicator of success in this process.
- A study conducted from 2017-2019 included 277 participants and found that adolescents had a significantly higher adherence rate (82.2%) compared to young adults (61.2%), with factors like age, academic struggles, and mental health affecting adherence.
- The findings suggest that tailored support and educational programs could help improve healthcare adherence among young adults with severe haemophilia.
Background: Women with hereditary fibrinogen disorders (HFDs) seem to be at an increased risk of adverse obstetrical outcomes, but epidemiologic data are limited.
Objectives: We aimed to determine the prevalence of pregnancy complications; the modalities and management of delivery; and the postpartum events in women with hypofibrinogenemia, dysfibrinogenemia, and hypodysfibrinogenemia.
Methods: We conducted a retrospective and prospective multicentric international study.